From the North: Take I-95 south, then take exit 2 towards ME-109/Wells/Sanford.  Turn right (west) onto Route 109 for .6 miles, then trun left (west) onto Route 9 for 6.7 miles.  Bear left (south) onto Route 4 for 6.4 miles. Arrive at 271 Main Street, South Berwick, Maine.  This should take you approximately 50 minutes to 1 hour.

From the South: Take I-93 North, at exit 27, turn left onto ramp for .5 miles towards RT-1/Tobin Bridge.  Road name changes to US-1, then take ramp (right) onto I-95 for 26.2 miles toward I-95/NH/Maine.  Stay on I-95 for 11.2 miles.  At Exit 3 stay on I-95 for .9 miles.  At exit 4, turn left onto ramp for 1.3 miles towards US-4/RT-16/NH Lakes/White Mtns/Spaulding Turnpike.  Take ramp (left) onto Route 16 (road name changes to US-4).  At Exit 7, turn right onto ramp towards RT- 108/Dover/Durham.  Turn right onto Route 108, then turn left onto Route 4 for 4.1 miles.  Bear left onto Route 236 for .2 miles. Arrive at 271 Main Street, South Berwick, Maine.  From Boston this trip should take approximately 1 hour 15 mins.