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Eosinophilia-myalgia syndrome

A probable autoimmune disorder precipitated by contaminated l-tryptophan tablets; characterized by fatigue, low-grade fever, myalgias, muscle tenderness and cramps, weakness, paresthesias of the extremities, and skin indurations; marked eosinophilia is noted on peripheral blood studies, serum aldolase is increased, and biopsies of peripheral nerve, muscle, skin, and fascia show microangiopathy and inflammation in connective tissue.

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