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Phosphodiesterase Inhibitors


Phosphodiesterase Inhibitors/Nutrient Depletion:
  • MelatoninMelatonin: Based on human and animal evidence, phosphodiesterase inhibitors like theophylline that reduce levels of vitamin B6 in the body may also deplete melatonin levels (11349394, 1806289).
  • PotassiumPotassium: Based on human evidence, theophylline derivatives may lower serum potassium levels (7646822).
  • Vitamin B6/pyridoxineVitamin B6/pyridoxine: Based on human evidence, theophylline may interfere with vitamin B6/pyridoxine metabolism (2535870).

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