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Amalaki (Phyllanthus emblica)



Interactions

Amalaki/Drug Interactions:
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on in vitro evidence, amalaki may have inhibitory effects on platelets (17). The effects of amalaki and antiplatelet or anticoagulant medications are not well understood.
  • Antidiabetic agentsAntidiabetic agents: Based on animal study, amalaki may reduce blood glucose (8; 24). Theoretically, concurrent use of amalaki and antidiabetic agents may increase the risk of hypoglycemia.
  • Antilipemic agentsAntilipemic agents: Based on human and animal study, amalaki reduces levels of cholesterol (10; 8). Theoretically, concurrent use of amalaki and antilipemic agents may have additive cholesterol-lowering effects.
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro and animal study, amalaki may induce tumor shrinkage and tumor cell apoptosis (26; 28; 29; 30; 31; 32; 1; 2; 3). The effects of amalaki and antineoplastic agents are not well understood.
  • Antituberculosis agentsAntituberculosis agents: In vitro, a 50% hydroalcoholic extract of Emblica officinalis fruit (EO-50) demonstrated protective effects against hepatotoxicity induced by the antituberculosis drugs rifampicin (RIF), isoniazid (INH), and pyrazinamide (PZA) (33).
  • DoxorubicinDoxorubicin: Based on in vitro study, alcoholic extract of amalaki may result in cardioprotective effects against doxorubicin toxicity (an approximately twelvefold doxorubicin IC50 increase) (19).
  • Iron saltsIron salts: Based on in vitro study, amalaki forms chelates with iron, reducing the amount of iron absorbed (15).

Amalaki/Herb/Supplement Interactions:
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on in vitro evidence, amalaki may have inhibitory effects on platelets (17). The effects of amalaki and antiplatelet or anticoagulant medications are not well understood.
  • Antilipemic agentsAntilipemic agents: Based on human and animal study, amalaki reduces levels of cholesterol (10; 8). Theoretically, concurrent use of amalaki and antilipemic agents may have additive cholesterol-lowering effects.
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro and animal study, amalaki may induce tumor shrinkage and tumor cell apoptosis (26; 28; 29; 30; 31; 32; 1; 2; 3). The effects of amalaki and antineoplastic agents are not well understood.
  • AntioxidantsAntioxidants: Based on animal and in vitro study, amalaki may inhibit reactive oxygen species (11; 14).
  • Antituberculosis agentsAntituberculosis agents: In vitro, a 50% hydroalcoholic extract of Emblica officinalis fruit (EO-50) demonstrated protective effects against hepatotoxicity induced by the antituberculosis drugs rifampicin (RIF), isoniazid (INH), and pyrazinamide (PZA) (33).
  • CopperCopper: Based on in vitro study, amalaki forms chelates with copper, reducing the amount of copper absorbed (15).
  • HypoglycemicsHypoglycemics: Based on animal study, amalaki may reduce blood glucose (8; 24). Theoretically, concurrent use of amalaki and antidiabetic agents may increase the risk of hypoglycemia.
  • ImmunosuppressantsImmunosuppressants: Based on in vitro evidence, amalaki may inhibit immune function. Theoretically, concurrent use of amalaki and immunosuppressants may cause additive immune suppressant effects (17).
  • IronIron: Based on in vitro study, amalaki forms chelates with iron, reducing the amount of iron absorbed (15).
  • Vitamin CVitamin C: When gooseberry juice was blended with other fruit juices for the preparation of ready-to-serve beverages, it boosted their nutritional quality in terms of vitamin C content (9).

Amalaki/Food Interactions:
  • Insufficient available evidence.

Amalaki/Lab Interactions:
  • CopperCopper: Based on in vitro study, amalaki forms chelates with copper, reducing the amount of copper absorbed (15).
  • GlucoseGlucose: Based on animal study, amalaki may reduce blood glucose (8; 24).
  • IronIron: Based on in vitro study, amalaki forms chelates with iron, reducing the amount of iron absorbed (15).
  • Lipid profileLipid profile: Based on human and animal study, amalaki may reduce serum cholesterol levels (10; 8).
  • Vitamin C levelsVitamin C levels: Consumption of amalaki may increase blood levels of vitamin C due to high levels of vitamin C in amalaki (9).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.