Table of Contents > Interactions & Depletions > Vitamin E Print

Vitamin E



Depletions

Vitamin E/Nutrient Depletion:
  • AnticonvulsantsAnticonvulsants: In human research, anticonvulsant drugs such as phenobarbital, phenytoin, or carbamazepine have been shown to decrease blood levels of vitamin E in handicapped patients (87; 88).
  • AntilipemicsAntilipemics: In human research, cholestyramine has been shown to reduce dietary vitamin E absorption and blood levels of vitamin E, as well as vitamin E levels in LDL (93; 94). However, this effect was not observed in a trial of cholestyramine combined with statins (95). In human research, colestipol has been shown to reduce dietary vitamin E absorption and blood levels of vitamin E (96; 97).
  • AntineoplasticsAntineoplastics: In human research, a transient decrease in alpha-tocopherol in erythrocyte membranes and an increase in alpha-tocopherol in lipoprotein fractions has been associated with letrozole therapy for four months (98). In human research, a significant decrease in serum alpha-tocopherol was observed in non-small cell lung cancer patients treated with gefitinib (99).
  • Antituberculosis agentsAntituberculosis agents: Antituberculosis drugs such as isoniazid have been shown to cause liver injury (100). In theory, use of isoniazid may reduce dietary vitamin E absorption and blood levels of vitamin E due to the liver's involvement in vitamin E kinetics.
  • Aromatase inhibitorsAromatase inhibitors: In human research, a transient decrease in alpha-tocopherol in erythrocyte membranes and an increase in alpha-tocopherol in lipoprotein fractions have been associated with letrozole therapy for four months (98).
  • Bile acid sequestrantsBile acid sequestrants: In human research, cholestyramine has been shown to reduce dietary vitamin E absorption and blood levels of vitamin E, as well as vitamin E levels in LDL (93; 94). However, this effect was not observed in a trial of cholestyramine combined with statins (95). In human research, colestipol has been shown to reduce dietary vitamin E absorption and blood levels of vitamin E (96; 97).
  • Cigarette smokeCigarette smoke: In human research, cigarette smokers showed significant lowering of alpha-tocopherol levels in plasma (116).
  • CopperCopper: In patients with G6PD deficiency, vitamin E supplementation has been shown to normalized elevated copper levels associated with the disease (117).
  • Gamma-tocopherolGamma-tocopherol: According to a review, alpha-tocopherol supplements have been shown to lower levels of gamma-tocopherol in the blood (3).
  • GefitinibGefitinib: In human research, a significant decrease in serum alpha-tocopherol was observed in non-small cell lung cancer patients treated with gefitinib (99).
  • GemfibrozilGemfibrozil: In human research, gemfibrozil has been shown to decrease serum levels of both alpha- and gamma-tocopherol, although the clinical significance of this is not clear (105).
  • IsoniazidIsoniazid: In theory, use of isoniazid may reduce dietary vitamin E absorption and blood levels of vitamin E due to the liver's involvement in vitamin E kinetics.
  • LetrozoleLetrozole: In human research, a transient decrease in alpha-tocopherol in erythrocyte membranes and an increase in alpha-tocopherol in lipoprotein fractions have been associated with letrozole therapy for four months (98).
  • Mineral oilMineral oil: According to secondary sources, mineral oil may reduce dietary vitamin E absorption.
  • Omega-6 fatty acidsOmega-6 fatty acids : According to secondary sources, increased intake of omega-6 fatty acids may increase vitamin E requirements, particularly at high doses.
  • OlestraOlestra: Although human research is mixed, olestra may reduce dietary vitamin E absorption and blood levels of vitamin E (124; 125; 126).
  • OrlistatOrlistat: In human research, orlistat has been shown to reduce dietary vitamin E absorption and blood levels of vitamin E (109; 110; 111; 112).
  • Stanyl estersStanyl esters: Stanyl esters have been proposed to reduce the absorption of fat-soluble vitamins. In human research, stanyl esters dissolved in margarine did not significantly affect the absorption of alpha-tocopherol (119).
  • SucralfateSucralfate: According to secondary sources, sucralfate may reduce dietary vitamin E absorption and blood levels of vitamin E.
  • Vitamin AVitamin A: Large doses of vitamin E may deplete vitamin A stores (53).
  • Vitamin KVitamin K: In adults not taking anticoagulants, high-dose vitamin E caused an increase in PIVKA-II (protein induced by vitamin K absence), indicating poor vitamin K status (121).

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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