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Related terms
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    Related terms
    • Brand Names: U.S.: Evista®
    • Brand Names: Canada: Apo-Raloxifene®;Evista®;Novo-Raloxifene;Teva-Raloxifene

    • It is used to put off soft, brittle bones (osteoporosis) in women after change of life.
    • It is used to stop breast cancer in women after the change of life who have soft, brittle bones (osteoporosis) or those with more of a chance of getting breast cancer.
    • When the body no longer makes estrogen, this drug puts back the estrogen.
    • Raloxifene stops estrogen from feeding estrogen-dependent cancer cells. This lowers the chance for spread of the cancer.


    How to take

    • Take this drug at the same time of day.
    • Take with or without food. Take with food if it causes an upset stomach.
    • This drug works best when used with calcium/vitamin D and weight-bearing workouts like walking or PT (physical therapy).
    • Follow the diet and workout plan that your doctor told you about.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.


    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.



    • This drug may raise the chance of a stroke or blood clots. Talk with your doctor.
    • Please read the medication guide.


    • If you have an allergy to raloxifene or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have blood clots or have had blood clots in the past.


    • If you have any blood flow problems, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have high triglycerides, talk with your doctor.
    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • Do not take colestipol or cholestyramine within 4 hours of this drug.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Limit your drinking of wine, beer, or mixed drinks.
    • Avoid being still for long periods of time (long trips, bed rest after surgery). Not moving for long periods may raise your chance of blood clots. Go back to normal activity as soon as you can.

    Side Effects

    • Swelling in the feet or hands.
    • Hot flashes. Wearing layers of clothes or summer clothes and staying in cool places may help.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loose stools (diarrhea).
    • Joint pain.
    • Leg cramps.
    • Not able to sleep.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
    • Chest pain or pressure.
    • Trouble breathing.
    • Swelling, warmth, or pain in the leg or arm.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Very loose stools (diarrhea).
    • A big weight gain.
    • Sudden change in eyesight, eye pain, or irritation.
    • A lump in the breast or breast soreness.
    • Very bad vaginal bleeding.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
    • Read the package insert for more details.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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