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Melatonin (N-acetyl-5-methoxytryptamine)


Melatonin/Nutrient Depletions:
  • CholesterolCholesterol: Melatonin may elicit decreases in free serum cholesterol levels (406).
  • Natural melatonin levels (decreases)Natural melatonin levels (decreases): Multiple drugs are reported to lower natural levels of melatonin in the body. It is not clear that there are any health hazards of lowered melatonin levels, or if replacing melatonin with supplements is beneficial. Examples of drugs that may reduce production or secretion of melatonin include nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®) (633; 634); beta-blocker blood pressure medications, such as atenolol (Tenormin®) or metoprolol (Lopressor®, Toprol®) (636; 637); and medications that reduce levels of vitamin B6 in the body, such as oral contraceptives, hormone replacement therapy, loop diuretics, hydralazine, and theophylline (638; 639; 640; 641). Anesthesia using 7% sevoflurane decreased melatonin blood concentrations (402). Asthmatics may have lower levels of endogenous melatonin (664; 665). Melatonin levels in serum decreased noticeably with propranolol treatment (635). Other drugs that may reduce melatonin levels (by inducing P450 1A2) include the following: carbamazepine, insulin, 3-methyl cholanthrene, modafinil, nafcillin, nicotine, omeprazole, phenobarbital, phenytoin, primidone, rifampin, and ritonavir, according to anecdotal information.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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