Table of Contents > Interactions & Depletions > Andrographis paniculata Nees, Kan Jang®, SHA-10 Print

Andrographis paniculata Nees, Kan Jang®, SHA-10



Interactions

Andrographis/Drug Interactions:
  • Allergy medicationsAllergy medications: Andrographolide may cause mast-cell stabilizing activity in rats and may interact or add to the effects of other medications.
  • Anticoagulants and anti-platelets Anticoagulants and anti-platelets : Use cautiously in patients taking anticoagulant agents such as warfarin (Coumadin®) or heparin or with anti-platelet agents such as ibuprofen (Motrin®, Advil®), due to possible platelet aggregation inhibition by andrographis (1).
  • Antidiabetic agentsAntidiabetic agents: Based on animal studies, there are possible hypoglycemic effects of andrographis (6), which may add to the effects of blood sugar-lowering agents, including insulin.
  • AntihypertensivesAntihypertensives: Based on animal studies, andrographis may lower blood pressure and may therefore add to the effects of antihypertensive medications (30).
  • Anti inflammatory agentsAnti inflammatory agents: Based on mechanism of action, andrographis and its constituents may have anti-inflammatory effects and thus may interact with other anti-inflammatory agents, including COX-2 inhibitors (32; 20; 33; 3; 34; 17; 35).
  • Antineoplastic agentsAntineoplastic agents: Based on several in vitro studies, andographolide may have anticancer effects (36; 37; 38).
  • Antiviral agentsAntiviral agents: There are historical data to suggest that andrographis has been effective in the past as part of a regimen to treat influenza in Asian medical systems. One randomized clinical trial using Kan Jang® reports a significant reduction in duration and severity of symptoms (39). Theoretically, interactions with other antivirals may occur.
  • Fertility agentsFertility agents: Animal studies suggest that andrographis may have antifertility or contraceptive effects at high doses (16).
  • ImmunomodulatorsImmunomodulators: Several systematic reviews and randomized, controlled trials indicate that andrographis may effectively treat upper respiratory infections (URIs) (25; 40; 29; 23; 24; 41; 22; 42; 28; 31). Many of these studies use andrographis in combination formulas containing other herbals (i.e. Kan Jang®), and thus it is difficult to define the role of andrographis alone; theoretically, interactions with other agents for URIs may occur.

Andrographis/Supplement Interactions:
  • Anticoagulants and anti-plateletsAnticoagulants and anti-platelets: Use cautiously in patients taking anticoagulant agents, such as warfarin (Coumadin®) or heparin, or with anti-platelet agents, such as ibuprofen (Motrin®, Advil®), due to possible platelet aggregation inhibition by andrographis (1). Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
  • Anti inflammatory herbsAnti inflammatory herbs: Based on mechanism of action, andrographis and its constituents may have anti-inflammatory effects and thus may interact with other anti-inflammatory agents, including COX-2 inhibitors (32; 20; 33; 3; 34; 17; 35).
  • AntineoplasticsAntineoplastics: Based on several in vitro studies, andographolide may have anticancer effects (36; 37; 38).
  • AntiviralsAntivirals: There are historical data to suggest that andrographis has been effective in the past as part of a regimen to treat influenza in Asian medical systems. One randomized clinical trial using Kan Jang® reports a significant reduction in duration and severity of symptoms (39). Theoretically, interactions with other antivirals may occur.
  • ContraceptivesContraceptives: Animal studies suggest that andrographis may have antifertility or contraceptive effects at high doses (16).
  • Hypoglycemics Hypoglycemics : Based on animal studies, there are possible hypoglycemic effects of andrographis (6), which may add to the effects of blood sugar-lowering agents.
  • HypotensivesHypotensives: Based on animal studies, andrographis may lower blood pressure and may therefore add to the effects of antihypertensive medications (30). Examples of agents with potential hypotensive properties include aconite/monkshood, arnica, baneberry, betel nut, bilberry, black cohosh, bryony, calendula, California poppy, coleus, curcumin, danshen, eucalyptol, eucalyptus oil, flaxseed/flaxseed oil, garlic, ginger, ginkgo, goldenseal, green hellebore, hawthorn, Indian tobacco, jaborandi, melatonin, mistletoe, night blooming cereus, oleander, pasque flower, periwinkle, pleurisy root, Polypodium vulgare, shepherd's purse, Texas milkweed, turmeric, and wild cherry.
  • ImmunomodulatorsImmunomodulators: Several systematic reviews and randomized, controlled trials indicate that andrographis may be effective in treating upper respiratory infections (URIs) (25; 40; 29; 23; 24; 41; 22; 42; 28; 31). Many of these studies use andrographis in combination formulas containing other herbals (i.e. Kan Jang®), and thus it is difficult to define the role of andrographis alone; theoretically, interactions with other agents for URIs may occur.

Andrographis/Food Interactions:
  • Insufficient available evidence.

Andrographis/Lab Interactions:
  • Blood pressureBlood pressure: Based on animal studies, andrographis may lower blood pressure and may therefore add to the effects of antihypertensive medications (30).
  • Coagulation panelCoagulation panel: Andrographis may inhibit platelet aggregation (1).
  • Serum glucoseSerum glucose: Based on animal studies, there are possible hypoglycemic effects of andrographis (6), which may add to the effects of blood sugar-lowering agents.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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