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Nonsteroidal Antiinflammatories (NSAIDS)


Nonsteroidal Antiinflammatories (NSAIDS)/Nutrient Depletion:
  • FolateFolate: Based on human evidence, non-steroidal anti-inflammatory drugs (NSAIDS), and aspirin in particular, may decrease serum folate levels, especially with chronic, large doses (1540135). Secondary sources suggest that rather than an actual folate deficiency, folate may be redistributed in the body; therefore folate supplementation may not be considered necessary. Based on in vitro evidence, many non-steroidal anti-inflammatory drugs (NSAIDs) were found to inhibit the folate-coenzyme-mediated biosynthesis of serine from glycine and formate (1540135).
  • IronIron: Based on anecdotal evidence, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) may cause mucosal damage and bleeding throughout the gastrointestinal tract. Chronic blood loss associated with long-term use of these agents may contribute to iron deficiency anemia. Because iron supplements may also irritate the gastrointestinal tract, iron-rich food intake may be advised as an alternative to use with NSAIDs.
  • MelatoninMelatonin: Based on animal evidence, non-steroidal anti-inflammatory drugs (NSAIDs) such as ketoprofen, phenylbutazone may suppress melatonin levels (9062866). Based on human evidence, ibuprofen (Motrin®, Advil®) or aspirin may suppress melatonin levels (8848472).
  • Vitamin C/ascorbic acidVitamin C/ascorbic acid: Based on human and animal evidence, aspirin may inhibit gastrointestinal absorption of vitamin C (6811490).
  • Vitamin KVitamin K: Based on animal evidence, high doses of salicylates may act as vitamin K-antagonists (3726797).
  • ZincZinc: Based on human evidence, aspirin and/or indomethacin may modulate blood levels of zinc (7063815).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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