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Related terms
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    Related terms
    • Brand Names: U.S.: Eligard®;Lupron Depot-Ped®;Lupron Depot®
    • Brand Names: Canada: Eligard®;Lupron®;Lupron® Depot®

    • It is used to treat endometriosis.
    • It is used to treat anemia caused by fibroids of the uterus.
    • It is used to treat prostate cancer.
    • It is used to delay puberty in children who are maturing too early.
    • It is used to treat breast cancer.
    • Leuprolide slows prostate cancer growth by lowering testosterone levels.
    • It lowers estrogen levels in women.
    • It lowers testosterone levels in men.


    How to take

    • It is given as a shot into the fatty part of the skin or a muscle.
    • Your doctor may teach you how to give the shot.
    • Wash your hands before and after use.
    • Throw away needles in a needle/sharp disposal box and take the box back to your doctor when it is full.

    Missed Dose

    • Call your doctor to find out what to do.


    • Eligard®, Lupron Depot-Ped®, Lupron Depot®
    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.
    • Leuprolide acetate 5 mg/mL solution:
    • If this drug is given at home, store unopened vials at room temperature or in the refrigerator. Do not freeze.
    • Protect from light.
    • Protect from heat.



    • If you have an allergy to leuprolide or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have vaginal bleeding and have not been to your doctor.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.


    • Use care if you have risks for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar (diabetes), cigarette smoking, man older than 40 years of age, other family members with early heart disease, woman after change of life). Talk with your doctor.
    • Disease signs may get worse before getting better.
    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have mental illness, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Birth control pills and other hormone-based birth control may not work to stop pregnancy. Use 2 kinds of birth control while taking this drug.

    Side Effects

    • Flushing. Wearing layers of clothes or summer clothes and staying in cool places may help.
    • More bone pain, blood in urine, and trouble passing urine. Most often gets better 1 to 2 weeks after care has started.
    • Weak bones with long-term use.
    • Swelling.
    • Headache.
    • Feeling tired or weak.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Low mood (depression).
    • Mood changes.
    • Not able to sleep.
    • Short-term vaginal bleeding.
    • Change in sex ability. This most often goes back to normal.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure.
    • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Change in thinking clearly and with logic.
    • Very bad problems with how you act.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Swelling, warmth, or pain in the leg or arm.
    • More bone pain after 2 to 4 weeks of care.
    • Very bad back pain.
    • Feeling very tired or weak.
    • Not able to pass urine.
    • Sudden change in eyesight.
    • Vaginal bleeding for more than 2 months.
    • Very bad skin irritation.
    • More trips to the bathroom, more thirst, or weight loss.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

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    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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