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Hibiscus (Hibiscus spp.)



Interactions

Hibiscus/Drug Interactions:
  • Anticancer agentsAnticancer agents: Hibiscus has shown anticancer effects in laboratory and animal studies (39; 40; 41; 42).
  • AntihypertensivesAntihypertensives: Two human studies have shown that extracts of hibiscus may lower the systolic and diastolic pressure (3; 4).
  • Anti-inflammatoriesAnti-inflammatories: Based on a pharmacokinetic study, zobo drink (made from hibiscus) may cause significant changes (p<0.05) in K-beta and t1/2beta of acetaminophen when given 90 minutes beforehand (43).
  • AntimalarialsAntimalarials: Based on a pharmacokinetic study, 500mg karkadi beverage (Hibiscus sabdarifa) may reduce antimalarial (quinine) efficacy (44).
  • AntiviralsAntivirals: Antiviral effects have been observed in preliminary laboratory study (45).
  • Chloroquine, Chloroquine: Based on a pharmacokinetic study, reduced effectiveness of chloroquine is possible (44).
  • Hormonal agentsHormonal agents: Based on a review of the literature, Hibiscus rosa-sinensis may have estrogenic activity, although the clinical significance is unclear (46).

Hibiscus/Herb/Supplement Interactions:
  • AntineoplasticsAntineoplastics: Hibiscus has shown anticancer effects in laboratory and animal studies (47; 48; 49; 50).
  • AntimalarialsAntimalarials: Based on a pharmacokinetic study, 500mg karkadi beverage (Hibiscus sabdarifa) may reduce the efficacy of antimalarial herbs and supplements (44).
  • AntiviralsAntivirals: Antiviral effects have been observed in preliminary laboratory study (51).
  • Hormonal agentsHormonal agents: Based on a review of the literature, Hibiscus rosa-sinensis may have estrogenic activity, although the clinical significance is unclear (46).
  • HypotensivesHypotensives: Two human studies have shown that extracts of hibiscus may lower the systolic and diastolic pressure (3; 4).

Hibiscus/Food Interactions:
  • Insufficient available evidence.

Hibiscus/Lab Interactions:
  • Blood pressureBlood pressure: Two human studies have shown that extracts of hibiscus may lower the systolic and diastolic pressure (3; 4).
  • Urinary concentrationsUrinary concentrations: In healthy men, consumption of Hibiscussabdariffa has resulted in significant decreases in the urinary concentrations of creatinine, uric acid, citrate, tartrate, calcium, sodium, potassium, and phosphate, but not oxalate (52).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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