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Fo-ti (Polygonum multiflorum)



Interactions

Fo-ti/Drug Interactions:
  • Antihyperglycemic drugsAntihyperglycemic drugs: Concomitant use of fo-ti with antidiabetic agents may increase the risk of hypoglycemia.
  • Calcium channel blockersCalcium channel blockers: Since fo-ti contains compounds that were found to inhibit the calcium channel, theoretically, it may produce a synergistic effect when taken with these drugs. The effect may be beneficial in some cases, but studies need to be done to further investigate this effect.
  • DigoxinDigoxin: The possible effect of fo-ti in causing hypokalemia may increase the risk of side effects from the use of digoxin. There are no documented cases of this interaction in the available literature.
  • Diuretic drugsDiuretic drugs: The effects of potassium loss may be enhanced if diuretics are used with fo-ti. This may lead to worsening of the symptoms of hypokalemia. However, there are no reports available in literature.
  • Estrogen-containing drugsEstrogen-containing drugs: Theoretically, fo-ti may interact with these types of drugs due to its estrogen content reported from an in vitro study (11).
  • LaxativesLaxatives: Theoretically, concomitant use of fo-ti with other laxatives can increase the risk of fluid and electrolyte depletion.
  • P450 enzyme affecting drugs (CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A4)P450 enzyme affecting drugs (CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A4): Data from an in vitro study looked fo-ti as one of the herbs that is an inhibitor of the CYP450 enzymes (12). This interaction may increase levels of drugs that are metabolized by these enzymes and lead to adverse effects.

Fo-ti/Herb/Supplement Interactions:
  • Cardiac glycoside herbs (similar to digoxin or foxglove)Cardiac glycoside herbs (similar to digoxin or foxglove): Theoretically, fo-ti may cause hypokalemia and increase the risk of side effects from the use of herbs such as foxglove and oleander that contain cardiac glycosides that behave similarly to digoxin.
  • Diuretic herbs and supplementsDiuretic herbs and supplements: Fo-ti may act as a weak diuretic and may reduce potassium levels. Use of fo-ti with other diuretic herbs and supplements may lead to hypokalemia. However, there are no reports available in literature.
  • Estrogenic/progestin herbsEstrogenic/progestin herbs: Theoretically, fo-ti may interact with these types of herbs and supplements due to its estrogen content reported from an in vitro study (11).
  • Hypoglycemic/hyperglycemic herbsHypoglycemic/hyperglycemic herbs: Concomitant use of fo-ti with antidiabetic agents may increase the risk of hypoglycemia.
  • Laxative herbsLaxative herbs: The use of laxative herbs including alder buckhorn, aloe, cascara, rhubarb, senna, and yellow dock, may contribute to additive laxative effects of fo-ti.
  • LicoriceLicorice: Licorice and fo-ti both have potassium-depleting properties, and, theoretically, may increase the risk of hypokalemia.
  • P450 enzyme affecting herbs (CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A4)P450 enzyme affecting herbs (CYP 1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A4): Data from an in vitro study looked fo-ti as one of the herbs that is an inhibitor of the CYP450 enzymes (12). This interaction may increase levels of herbs or supplements that are metabolized by these enzymes and lead to adverse effects.

Fo-ti/Food Interactions:
  • Diuretic foods (e.g. celery, watermelon, asparagus and parsley)Diuretic foods (e.g. celery, watermelon, asparagus and parsley): Theoretically, any foods that may have diuretic effects may interact with fo-ti and reduce electrolytes.

Fo-ti/Lab Interactions:
  • CholesterolCholesterol: Theoretically, cured fo-ti may reduce serum total cholesterol concentrations and test results.
  • Colorimetric testingColorimetric testing: Fo-ti may cause discoloration of urine (pink, red, orange, rust), and may therefore interfere with diagnostic tests that depend on a color change, due to its anthraquinone content.
  • GlucoseGlucose: Theoretically, fo-ti may decrease blood glucose levels and test results (13).
  • PotassiumPotassium: Chronic use of fo-ti may cause hypokalemia, reducing serum potassium concentrations and test results due to its anthraquinone contents (9).
  • TriglyceridesTriglycerides: Theoretically, cured fo-ti might reduce serum triglyceride concentrations and test results (9).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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