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American wormseed (Chenopodium ambrosioides, Dysphania ambrosioides)



Interactions

American wormseed/Drug Interactions:
  • Antifungal agentsAntifungal agents: When wormseed was tested against the aflatoxigenic strain of Aspergillus flavus, the oil completely inhibited the mycelial growth at 100mcg/mL (2). The oil exhibited a broad fungitoxic spectrum against Aspergillus niger, Aspergillus fumigatus, Botryodiplodia theobromae, Fusarium oxysporum, Sclerotium rolfsii, Macrophomina phaseolina, Cladosporium cladosporioides, Helminthosporium oryzae, and Pythium debaryanum at 100mcg/mL. However, an indifferent effect has been found for combinations of meglumine antimonate or amphotericin B and the essential oil (19). Theoretically, concurrent use with antifungal agents may have additive effects.
  • Antineoplastic agentsAntineoplastic agents: In an animal study of intraperitoneal administration of wormseed (5mg/kg) on Ehrlich tumor development, a potent antitumor effect was evident (5). An in vitro study of different tumor lines (CCRF-CEM, HL60, MDA-MB-231) found that ascaridole exerted antineoplastic activity and may be an interesting novel candidate drug for cancer treatment (6). Methanolic extracts (a preparation using the solvent methanol) from wormseed showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2 (20). Theoretically, concurrent use with antineoplastic agents may have additive effects.
  • Antiparasitic agentsAntiparasitic agents: The leishmanicidal effect of an essential oil from wormseed has been demonstrated in animal studies (21; 22; 7). The in vitro antileishmanial effect of the essential oil from wormseed against Leishmania donovani showed significant activity against promastigotes and amastigotes, with a 50% effective concentration of 4.45 and 5.1mcg/mL, respectively (23). The in vitro effects of wormseed extracts were studied, with a reduction of more than 95% of the infective nematode larvae in the concentration of 110.6mg/mL (24). Theoretically, concurrent use with antiparasitic agents may have additive effects.

American wormseed/Herb/Supplement Interactions:
  • AntifungalsAntifungals: When wormseed was tested against the aflatoxigenic strain of Aspergillus flavus, the oil completely inhibited the mycelial growth at 100mcg/mL (2). The oil exhibited broad fungitoxic spectrum against Aspergillus niger, Aspergillus fumigatus, Botryodiplodia theobromae, Fusarium oxysporum, Sclerotium rolfsii, Macrophomina phaseolina, Cladosporium cladosporioides, Helminthosporium oryzae, and Pythium debaryanum at 100mcg/mL. However, an indifferent effect has been found for combinations of meglumine antimonate or amphotericin B and the essential oil (19). Theoretically, concurrent use with antifungal agents may have additive effects.
  • AntineoplasticsAntineoplastics: In an animal study of intraperitoneal administration of wormseed (5mg/kg) on Ehrlich tumor development, a potent antitumor effect was evident (5). An in vitro study of different tumor lines (CCRF-CEM, HL60, MDA-MB-231) found that ascaridole exerted antineoplastic activity and may be an interesting novel candidate drug for cancer treatment (6). Methanolic extracts (a preparation using the solvent methanol) from wormseed showed cytotoxic activity against a human hepatocellular carcinoma cell line, Hep G2 (20). Theoretically, concurrent use with antineoplastic agents may have additive effects.
  • AntiparasiticsAntiparasitics: The leishmanicidal effect of an essential oil from wormseed has been demonstrated in animal studies (21; 22; 7). The in vitro antileishmanial effect of the essential oil from wormseed against Leishmania donovani showed significant activity against promastigotes and amastigotes, with a 50% effective concentration of 4.45 and 5.1mcg/mL, respectively (23). The in vitro effects of wormseed extracts were studied, with a reduction of more than 95% of the infective nematode larvae in the concentration of 110.6mg/mL (24). Theoretically, concurrent use with antiparasitic agents may have additive effects.

American wormseed/Food Interactions:
  • Insufficient available evidence.

American wormseed/Lab Interactions:
  • Insufficient available evidence.

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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